Hypertension in pregnancy management

 Hypertension in pregnancy


Advise pregnant women at high risk of pre-eclampsia to take 75–150 mg of aspirin daily from 12 weeks until the birth of the baby , those with any of the following: •hypertensive disease during a previous pregnancy

•chronic kidney disease

• autoimmune disease such as systemic lupus erythematosus or antiphospholipid syndrome

• type 1 or type 2 diabetes • chronic hypertension.


Advise pregnant women with more than 1 moderate risk factor for preeclampsia to take 75–150 mg of aspirin. Factors indicating moderate risk are: • first pregnancy • age 40 years or older • pregnancy interval of more than 10 years • body mass index (BMI) of 35 kg/m2• family history of pre-eclampsia •multi -fetal pregnancy


Stop antihypertensive treatment in women taking ACE inhibitors or ARBs if they become pregnant (preferably within 2 working days of notification of pregnancy) and offer alternatives. 

 Advise women who take thiazide or thiazide-like diuretics:• that there may be an increased risk of congenital abnormalities and neonatal complications if these drugs are taken during pregnancy.


Offer antihypertensive treatment to pregnant women who have chronic hypertension and who are not already on treatment if they have: • sustained systolic blood pressure of 140 mmHg or higher or • sustained diastolic blood pressure of 90 mmHg or higher. 


When using medicines to treat hypertension in pregnancy, aim for a target blood pressure of 135/85 mmHg.


 Consider labetalol to treat chronic hypertension in pregnant women. Consider nifedipine for women in whom labetalol is not suitable, or methyldopa if both are not suitable.


Timing of birth::

 Do not offer planned early birth before 37 weeks to women with chronic hypertension whose blood pressure is lower than 160/110 mmHg, with or without antihypertensive treatment, unless there are other medical indications.

 For women with chronic hypertension whose blood pressure is lower than 160/ 110 mmHg after 37 weeks, with or without antihypertensive treatment, timing of birth and maternal and fetal indications for birth should be agreed between the woman and the senior obstetrician.


Postnatal investigation, monitoring and treatment::

 In women with chronic hypertension who have given birth, measure blood pressure: • daily for the first 2 days after birth • at least once between day 3 and day 5 after birth • as clinically indicated if antihypertensive treatment is changed after birth. 

 In women with chronic hypertension who have given birth: • aim to keep blood pressure lower than 140/90 mmHg• continue antihypertensive treatment, if required• offer a review of antihypertensive treatment 2 weeks after the birth, with their GP or specialist. 


 If a woman has taken methyldopa to treat chronic hypertension during pregnancy, stop within 2 days after the birth and change to an alternative antihypertensive treatment.

Offer women with chronic hypertension a medical review 6–8 weeks after the birth with their GP or specialist as appropriate.


Offer enalapril to treat hypertension in women during the postnatal period, with appropriate monitoring of maternal renal function and maternal serum potassium.

 For women of black African or Caribbean family origin with hypertension during the postnatal period, consider antihypertensive treatment with: • nifedipine or • amlodipine if the woman has previously used this to successfully control her blood pressure. 

 For women with hypertension in the postnatal period, if blood pressure is not controlled with a single medicine, consider a combination of nifedipine and enalapril. If this combination is not tolerated or is ineffective,

consider either: • adding atenolol or labetalol to the combination treatment or • swapping 1 of the medicines already being used for atenolol or labetalol.

 When treating women with antihypertensive medication during the postnatal period, use medicines that are taken once daily when possible.

 Where possible, avoid using diuretics or angiotensin receptor blockers to treat

hypertension in women in the postnatal period who are breastfeeding or expressing milk. 


Source:: NICE guidance


By:: Dr. Manilal Biswas

SSMC (2012-13)

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